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How Exosome Therapy Differ from Stem Cell Therapy

Exosomes are potent microvesicles released by adult mesenchymal stem cells. They have the ability to help restore cells in the body by improving cell to cell communication.

Exosomes are not cells, and they are smaller than cells. When compared to adult stem cells, exosomes have much more growth factors which give them a better clinical and aesthetic potential than stem cells.

It’s a cell-free cell therapy, this makes it safer compared to other cellular therapy, because there’s no risk of rejection in graft Vs host.

Unlike some other cellular therapies, exosomes do not produce host graft reactions, because they do not carry HLA genetic information and are not cells but extracts of the cells (released by cells).

Exosomes have a superior regenerative capacity, because they are obtained from newborn umbilical cord tissue mesenchymal cells, which means they have not been exposed to any contaminating or toxic agent because our cells are as healthy as our body.

Exosomes improve the signaling between cells, thereby making them useful to revitalize, rejuvenate, restore, and cause anti-inflammatory effects in the body.

When compared to autologous adult stem cells, exosomes have much more healthy growth factors which gives them a better clinical and aesthetic potential than stem cells.

Exosomes are less complicated products to transport because the cells used in cellular therapy must be applied to the patient very quickly because they are live cells. In the laboratory, once they are thawed the doctors have limited time to apply them. However, with exosomes, they last longer, because as they are proteins they do not denature and can last for longer periods.

Exosomes is a superior product to autologous treatments because they do not require a surgical procedure, they come in a vial that can be injected directly, significantly reducing the risk and complications of a surgical procedure.

It is a superior product to autologous stem cell therapy because the patient’s cells have the same age and the same quality. For example, if a patient is a smoker and intoxicated, obviously the health of his cells is not the best. That is why the most indicated product is a donor product that is pure and free of toxins.

Mesenchymal cell-derived exosomes are preferably used in regenerative medicine. These cells are excellent regenerative cells due to their multipotent nature, therefore MSCs derived exosomes are superior to other exosomes products.

The Cellgenic lyophilized exosomes are derived from mesenchymal cells, which makes it superior to other exosome products, because mesenchymal cells have superior and excellent regenerative capacity.

This is why exosome therapy, especially Cellgenic lyophilized exosomes should be a doctor’s first choice.

Applications of Exosomes in Regenerative Medicine

In recent years, the application of exosomes in regenerative medicine has been growing. Also, many more potential applications of exosomes in regenerative medicine are still being studied.

In this article, you’ll learn the functions of exosomes and up-to-date applications of exosomes in regenerative medicine.

What are exosomes?

Exosomes are tiny vesicles that play a crucial role in cell to cell communication. Every cell in our body produces exosomes, to give information to the neighboring cells or long-distance cells, to change their behavior or to simply share information.

They transfer genetic information, proteins, and receptors, and they are capable of changing the behavior of one cell to the other. They have the ability to increase cell replication and other substances crucial for tissue regeneration.

Functions of exosomes

The major function of exosomes is to improve intercellular communication by releasing effectors and signaling molecules between cells.

Every cell in our body produces exosomes, to give information to the neighboring cells, or long distance cells, to change their behavior or to simply share information.

They transfer genetic information, proteins, and receptors, and are capable of changing the behavior of one cell to the other. They can increase cell replication and other substances crucial for tissue regeneration.

Exosomes affect all aspects of cell biology and are useful for improving intercellular communication.

Various applications of exosomes in regenerative medicine. 

Exosomes have various clinical applications due to their high potency, reduced immunogenicity, and ability to cross physiological barriers such as the blood-brain barrier.

In regenerative medicine, exosomes can be used in a point of care environment for a lot of aesthetic and therapeutic purposes.

The Use of Exosomes in Hair therapy

Exosomes can be used in the early stages of hair loss to re-grow and regenerate hair.

The good thing about using exosomes for hair loss is that they can be used in both men and women.

Exosomes can help stimulate hair growth and prevent hair loss. Clinical results have also shown the efficacy of exosomes in alopecia areata.

Exosomes from follicular stem cells are said to inhibit hair loss and promote hair growth.

In the earlier stages of hair loss, hair can be regrown and regenerated in men and women by administering exosomes and growth factors. 

After the first round of exosome therapy, noticeable change can be seen in 2 or 3 months but the most significant changes start from 6 to 12 months. 

The Use of  Exosomes in Skin-Regeneration

There are so many research and clinical trials surrounding the application of exosomes in skin treatment.

The benefits of exosome therapy in skin regeneration because of their ability to directly stimulate target cells, non-immune rejection and high stability.

These are some of the abilities of exosomes in skin regeneration:

  • Regulation of inflammation
  • Synthesis of collagen
  • Angiogenic effect

The Anti-aging effect of exosomes

Exosomes can be used to restore aging tissues of the body due to their outstanding regenerative ability.

Signs of aging manifest due to the skin’s inability to regenerate itself, exosomes can help to maintain the skin’s elasticity and strength.

Exosome therapy is changing the approach to anti-aging treatment. The rejuvenation capability of exosomes is a great way to make your patients feel young again.

It revitalizes senescent cells by repairing damage due to aging.

With exosomes, you are improving longevity by reversing the cells that are dying due to aging.

Exosomes in Pain management

Exosome therapy can be used to relieve pain by subduing pain signals, reducing inflammation and repairing damaged tissues.

The application of Exosome in inflammatory conditions.

Exosomes can decrease inflammation, regenerate cells and modulate the immune system.

Osteoarthritis: MSC-derived exosomes can reduce the joint inflammation in osteoarthritis and also stimulates cartilage regeneration and the repair of damaged tissues.

Tendinitis: Tendinitis is the inflammation of tendons. Exosomes can reduce the inflammation associated with tendinitis and repair torn tendons and muscles.

Due to the potency of exosomes and its paracrine effect, the potential capabilities of exosomes are still being discovered and studied.

At Cellgenic, we prepare easy to transport and administer Lyophilized exosomes, suitable for use in regenerative medicine.

How much does exosome therapy cost?

Exosome therapy is the new buzz in the regenerative medicine industry because of how it can repair and regenerate your cells and tissues.

Exosome therapy is safer compared to other cellular therapy because it’s a cell-free therapy with no risk of rejection.

Exosome therapy will be beneficial to you if you’re dealing with conditions such as sport injuries, tissue regeneration,  hair loss, erectile dysfunction, chronic pain and so many other applications . 

In this article, you’ll be learning the cost of exosome therapy and how you can benefit from exosome therapy.

How the cost of exosome therapy is determined

All cells produce exosomes, which are microvesicles that contain biochemical and genetic information. 

Hence, the cost of an exosome product (used in exosome therapy) will depend on what type of cell line (raw tissue source) used to extract the exosomes.

The first factor to determine the cost of an exosome product depends on the quality of the tissue source.

The most commonly used tissue types are cord blood, amniotic fluid and mesenchymal cell cultures.

Exosomes derived from mesenchymal cell cultures are the most difficult to obtain but offer the greatest therapeutic potential.

How much does exosome therapy cost?

The average cost of exosome therapy is $4,900, but the price can be anything from $3,500 – $6,500.

It’s also important to note that the price depends on your specific needs and your treatment plan, as decided by the doctor.

The doctor will schedule a consultation with you to determine your personalized treatment plan.

The exosome therapy can either be given as an IV infusion or as localized injections, depending on the purpose of the therapy.

Exosomes are very useful to revitalize, rejuvenate, restore, and reduce inflammations in the body.

Here are some ways you can benefit from exosome therapy

Hair loss therapy: If you’re in the early stages of hair loss, with exosome therapy you can regenerate your hair whether you’re a man or woman. After exosome therapy, you’ll start seeing new hair growth in as little as two to three months with very significant results showing 6 months or 1 year later.

Chronic pain: In case you’re experiencing chronic pain due to degenerative conditions such as arthritis, exosomes can help to subdue the pain by regenerating the cells and helping the body work better.

Degenerative conditions: If you’re struggling with degenerative medical conditions such as osteoarthritis and musculoskeletal injuries, exosome therapy can help your body repair the damage done to your cells by these conditions, prevent them from getting better, and help you to feel better.

Skin therapy: exosome therapy can reduce inflammation in the skin by improving the strength and elasticity of the skin.

Anti-aging: if you would like to retain your youthful glow, exosome therapy can make you feel young again by rejuvenating your skin due to its ability to reverse the cells dying due to aging.

Where can you get exosome therapy?

Cellular hope institutes provide exosome therapy for patients looking for better outcomes for various conditions.

The exosomes used at Cellular Hope Institute are obtained from umbilical cord tissue that is discarded after a new birth , which means these Exosomes have not been exposed to any contaminating or toxic agent because our cells are as healthy as our body. This gives it a higher capacity to regenerate your cells and tissues.

Culture Expanded MSCs

Mesenchymal Stem Cells (MSCs) are the most commonly used cells in stem cell therapy and regenerative medicine, due to their high and multi-potency. Mesenchymal Stem Cells (MSCs) can be isolated from different tissues in the body.

In this article, you’ll be learning about culture-expanded MSCs, how MSCs can be expanded, The potency of MSCs and the type of cells they can differentiate into.

What are culture expanded Mesenchymal Stem cells?

Mesenchymal stem cells are high potent cells used for cellular therapy and isolated from different parts of the body. Mesenchymal stem cells can be used to improve the patient outcome in diseases and conditions such as autoimmune diseases, degenerative diseases, nerve damage, diabetes mellitus, bone problems etc.

For every patient, millions of mesenchymal stem cells are needed and the exact amount varies according to disease, route of administration, administration frequency, weight, and age of patient.

Mesenchymal stem cells are expanded in a culture media, on a large scale in order to obtain the required quantity of cells needed for cellular therapy.

Culture expanded MSCs: How does it work?

Expanding Mesenchymal stem cells in a media involves step by step process of isolation and expansion.

Mesenchymal Stem Cells Isolation

Mesenchymal stem cells can be isolated from different tissues in the human body such as adipose tissues, dental pulp, human bone marrow, umbilical cord tissue, umbilical cord blood, peripheral blood and synovium.

Mesenchymal stem cells are expanded in culture to increase their yield and amplify their desired functions and potency.

Although the population of Mesenchymal Stem Cells obtained will vary from donor to donor, here are some steps to follow:

· Acquire fresh tissue extracts in strictly aseptic conditions, to maintain purity.

· To remove any cell clusters, you have to filter the cell suspension with a 70-mm filter mesh

· Use a centrifuge to roll the cells for about 5 minutes at 500g

·  Suspend the cells again the cells to measure the cell viability and yield using Trypan blue exclusion

· Use in T75 culture dishes to culture the cells in 10 mL of complete MSC medium at a density of 25 × 106 cells/mL. You can then go on to Incubate the plates at 37 °C with 5% CO2 in a humidified chamber without any interruption.

· When it’s past 3 h, remove the non-adherent cells that accumulate on the surface of the dish by changing the medium and replacing it with 10 mL fresh complete medium.

·  After an additional 8 h of culture, add 10ml fresh complete medium as a replacement for the existing medium. You’ll have to repeat this step every 8 h for up to 72 h of initial culture.

· Cells can be frozen in MSC growth media plus 10% DMSO (D2650) at a density of 2X106 cells/vial.

Expansion of Mesenchymal Stem Cells in a culture media

Culture expanded mesenchymal cells undergo various stages from the preparation of the culture plate, thawing of Mesenchymal stem cells, and the actual expansion of Mesenchymal stem cells.

The reason behind the cultural expansion of Mesenchymal stem cells is to get them to differentiate into other cell types such as osteoblast, adipocyte, and mesenchymal stromal cells.

In preparation, to expand MSCs in a culture media, you need a culture ware. You can get one plastic or glassware plate and coat it with a sufficient amount of 0.1% gelatin. Don’t forget to aspirate the gelatin solution from the coated plate or flask before you use it.

The next step involves the thawing of the Mesenchymal stem cells, and here are a few steps for you to follow:

After the recommended culture medium and coated culture ware is ready and on standby, remove the vial of Mesenchymal Stem Cells from liquid nitrogen and incubate in a 37C water bath and pay close attention to it, until all the cells are completely thawed. The extent of completely thawed frozen cells and how fast, are what determines the cell viability.

Once the cells have thawed completely, take steps to avoid contamination by disinfecting the walls with 70% ethanol, before you proceed to the next step.

Place the cells in a hood, and carefully transfer the cells to a sterile tube with a pipette (1 or 2ml pipette), Do this in such a way to prevent bubbles.

Then, add drops of Mesenchymal Stem cell expansion medium that have been pre-warmed to 37C to the tube containing the Mesenchymal stem cells.

Be careful to take your time when adding the medium to avoid osmotic shock which could lead to decreased viability.

Proceed to mix the suspension slowly by pipetting up and down two times while avoiding any bubbles.

Place the tube in a centrifuge and centrifuge the tube at 300 x g for 2-3 minutes to roll the cells, and you should not vortex the cells.

After this, then decant as much of the supernatant as possible. These steps are necessary to remove residual cryopreservative (DMSO).

Suspend the cells in a total volume of 10 mL of Mesenchymal Stem Cell Expansion Medium again or any alternative of choice, pre-warmed to 37 °C, containing freshly added 8 ng/mL FGF-2 (F0291).

The next step involves placing the cell suspension onto a 10-cm tissue culture plate or a T75 tissue culture flask.

Maintain the cells in a humidified incubator at 37 °C  with 5% CO2.

The next day, exchange the medium with fresh Mesenchymal Stem Cell Expansion Medium (pre-warmed to 37 °C) containing 8 ng/mL FGF-2*. Replace with fresh medium containing FGF-2 every two to three days thereafter.

Isolate the cells when they are approximately 80% confluent, using Trypsin-EDTA and passaged further or frozen for later use.

Expansion of Mesenchymal Stem Cells

Once the cells are actively proliferating and have reached a confluence of approximately 80% (before 100%), you should subculture the cells.

Then remove the medium from the 10-cm tissue culture plate containing the confluent layer of human mesenchymal stem cells, carefully and apply 3-5 mL of Trypsin-EDTA Solution, before proceeding to incubate in a 37 °C incubator for 3-5 minutes.

Crosscheck the culture to see if all the cells are completely detached. Then, add 5 mL Mesenchymal Stem Cell Expansion Medium to the plate.

Swirl the plate mildly to mix the cell suspension. Transfer the separated/isolated cells to a 15 mL conical tube.

Centrifuge the tube at 300 x g for 3-5 minutes to pellet the cells.

Throw the supernatant away and apply 2 mL Mesenchymal Stem Cell Expansion Medium (pre-warmed to 37 °C) containing 8 ng/mL FGF-2 to the conical tube and completely suspend the cells again. Remember not to vortex the cells.

Then, use a hemocytometer to count the number of cells.

Plate the cells at a density of 5,000-6,000 cells per cm2 into the appropriate flasks, plates, or wells in a Mesenchymal Stem Cell Expansion Medium containing 8 ng/mL FGF-2.

Cells can be frozen in MSC growth media plus 10% DMSO (D2650) at a density of 2X106 cells/vial.

Functions of Culture Expanded MSCs

Mesenchymal stem cells are required to be expanded in order for them to be used clinically for therapeutic purposes.

The culture expanded MSCs can be induced to differentiate into adipocytes, osteocytes, hepatocytes, chondrocytes, tenocytes and cardiomyocytes.

Because of its potential to differentiate into different kinds of cells in the body, it can be used to manage liver problems, heart problems, joint and bone problems etc.

Mesenchymal stem cells are also used in tissue regeneration and modulation of the immune system. They possess anti apoptotic, angiogenic, anti fibrotic, and anti-oxidative properties.

However, the quantity of MSCs isolated from body tissues is not enough for clinical and therapeutic applications.

This is why MSCs are expanded in culture to increase their yield for desired therapeutic effect.

Why cellular therapies have become a standard in clinics that are betting on biological medicine

Cellular therapy is fast becoming a standard therapy in many regenerative clinics today.  Many doctors are no longer questioning the safety and effectiveness of stem cell therapy. This is because various stem cell studies are already describing the benefits of stem cells for patients who are living with chronic and autoimmune health conditions.

This article will be talking about why stem cell therapy have become a standard therapy in clinics, the paracrine effect of stem cells, and other reasons why doctors are adopting stem cells in their clinics.

Benefits of stem cell therapy

Stem cell therapy is an important innovation in medicine because of its regenerative power in the human body. Most disease states are characterized by damaged cells, tissues and organs, which is where stem cell therapy comes in. In stem cell therapy, stem cells are administered into the human body and it replaces the cells damaged by disease or health disorders.

Stem cell research has revealed two major ways of using stem cells to rebuild defective and damaged cells. One of these ways can be seen in procedures like bone marrow transplant, where stem cells are used to replace the damaged cells by engraving, and they then differentiate into the proper cell type. Another mechanism relies on the paracrine effect of stem cells. This procedure of stem cell therapy involves using stem cells isolated from a donor to stimulate the patient’s cells to repair damaged tissues.

Additionally, unlike traditional therapy, stem cells have a wide application. Stem cell therapy is used to manage various degenerative diseases, autoimmune disorders, birth defects, and the research is still ongoing for so many other health conditions where stem cells have shown potential.

Also, there is currently a high demand for aesthetic medicine. Stem cell therapy is a proven alternative to other forms of cosmetology such as plastic surgery. Hence, dermatologists are turning to stem cell therapy to administer anti-aging procedures, skin rejuvenation, hair therapy, micro-needling etc.

The Paracrine effect of stem cells

The paracrine effect of stem cells is one of the most outstanding effects of stem cells. It involves using donor cells to stimulate endogenous repair by harnessing the regenerative power of the human body. It is a mechanism of tissue regeneration that has created new possibilities for managing various conditions using stem cell therapy.

The cells that trigger a paracrine response are; mesenchymal cells, umbilical cord blood, umbilical cord tissue, adipose (fat) tissue and blood cells from a donor’s bone marrow.

The paracrine effect occurs when the donor’s cells send the damaged or defective cells signals to induce self regeneration and repair by secreting some factors and proteins. One of the mechanism by which this paracrine effect is initiated, involves the secretion of cytokines and regulatory proteins by the damaged patient’s cells, these cytokines and proteins act as mediators to stimulate an immune response that attracts the donor cells, this causes the donor cells to release proteins and factors that stimulate the patient’s cells to promote cell proliferation, increase vascularization and blood flow to the areas that needs to heal, while reducing inflammation.

Moreover, research has shown that the paracrine effect of stem cells prevents damaged and diseased cells from dying. They are also therapeutically useful in autoimmune diseases and preventing transplant rejection due to the immune suppression effect they have.

Is stem cell therapy effective?

Doctors are always looking for ways to provide the best possible treatment to their patients, and that is why many clinics are embracing stem cell therapy as a standard, due to its many advantages.

Stem cell therapy is one of the most effective and safest therapy patients can receive, when compared to other existing treatment options.  Stem cell therapy is used in promoting patient outcomes in a lot of disease conditions that were previously poorly treated by other alternatives.

Again, as new potentials and ways of applying stem cells are being discovered, doctors are beginning to maximize these benefits in their clinics. Some conditions that are currently treated by stem cells include autoimmune conditions, immunotherapy Car-T cells, chronic obstructive pulmonary disease, neurodegenerative conditions, osteoarthritis, spinal cord injury, aesthetics/anti-aging, sports medicine, autism and multiple sclerosis.

Another reason clinics are adopting stem cell therapy as a standard therapy is because it is easy to administer. A lot of machines such as GCELL {Insert link} which makes the harvesting and processing of stem cells easy and fast, have made the procedures easily adaptable by doctors.

Furthermore, stem cell therapy reduces the treatment and recovery time associated with surgical procedures and other treatment options. This alone is a big factor in why stem cells are becoming a standard therapy in clinics.

Therapeutic uses of stem cells vs traditional medicine

Existing stem cell research has shown how the regenerative effect of stem cells is defining the future of medicine. The major advantage of stem cell therapy over conventional medication-based therapy is its safety. Stem cell therapy is aimed at treating the cause of the disease while traditional medicine targets the symptoms.

 Another problem with traditional medical therapy is that it introduces another problem while trying to solve the existing one. As a doctor, you always run the risk of causing harm with each prescription because of various adverse effects that could lead to major organ damage of the kidney, liver etc.  On the other hand, patients already know this and they are actively seeking better alternatives, this is why stem cell therapy is fast becoming a standard therapy in clinics.

Moreover, doctors will always be concerned about whether their patients are taking their medications or not. The burden of drug compliance and adherence associated with traditional medical therapy is not always easy to navigate. This is why effective treatment options like stem cell therapy have become a standard therapy in clinics. It only requires the patients having a procedure that repairs and restores damaged cells and tissues in the most natural way.

If you would like to become certified in regenerative medicine using stem cells and other cellular therapy, contact us.

How Exosomes Can Revolutionize Your Healthcare Practice

Cellgenic has worked closely with physicians all around the world for over a decade, and in working shoulder to shoulder with the rest of the medical community, we’ve gotten a feel for what we feel their main grievances are when incorporating regenerative medicine into their practice. We’ve found that primarily, the largest hurdles have been the large upfront costs, the long procedure times, and the difficulty procuring patients. 

For a long time, most of the history of the nascent field of regenerative medicine, physicians would have to spend multiple thousands of dollars training themselves to use the procedures required to treat patients. In order to use this training, they would need to buy large, heavy, and expensive medical processing equipment in order to actually process the cellular samples. And after that, they would have to go through the trouble of procuring the enzymes and medical supplies needed to perform the procedure itself.

Every step of the process was mired with difficulty, and all of this was before even the patient acquisition process, which has the potential to completely make or break a practice. This is to not even mention the procedure itself, which can take anywhere from three to five hours of a physician being on their feet, and a patient being subdued under local anesthesia. The final result is an uncomfortable and drawn out procedure that regenerative medicine physicians have been working for years to optimize. 

Cellgenic Exosomes is the company’s flagship product, which stands ready to revolutionize the practice of regenerative medicine as we know it today. Exosomes are extracellular vesicles which float freely within the blood, very much like platelets. But that is where the similarities end, because exosomes have been recently discovered to do far more than previously thought. Current science has identified them as one of the cornerstones of intercellular communication, as the enzymes that they secrete are responsible for cell-signalling, including calling healthy cells to begin the process of repairing damaged tissue. Because they consist of proteins, they are able to be administered without a risk of rejection from the patient, and they’re able to immediately get to work within the body, utilizing their growth factors and anti-scarring proteins to target inflammation and damaged tissue within the body. 

Utilizing a potent combination of growth factors and anti-scarring proteins, they target inflammation and damage within the cells and tissues of the body and begin repairing it. The administration of Cellgenic Exosomes is simple. Every order arrives cryogenically-preserved under dry ice, and from there physicians can store them in the freezer for over one year. To administer, they simply need to be thawed out and injected into the patient, without the need for expensive and bulky equipment. All in all, this new process should not take more than forty-five minutes, and has lower upfront costs than the previous standard of care for regenerative medicine practitioners. 

For more information, please visit https://cellgenic.com/, or contact info@stemcellsgroup.com

How Cellgenic MSCs Revolutionize Regenerative Medicine

Stem Cells are revolutionizing the field of regenerative medicine, due to their intelligence. Once administered into the patient, they are able to identify and target areas of disease and damage. Adimarket’s Mesenchymal Stem Cell Product excretes growth factors, cytokines, and proteins, which all play a key role in the regeneration of tissue. Their anti-inflammatory and immunomodulatory properties mean that it is difficult for them to be rejected by the body. Additionally, they increase blood flow to the vital organs which need it the most. 

Many proprietors of  MSC products will claim that it is not necessarily important to have a high ratio of viable cells. They claim that it does not matter how many cells are ‘not viable’, or dead, so long as there is a high enough number of viable cells– however, current research has shown that this is not the case. These dead cells are detectable by the immune system, and it is believed that they can create an inflammatory response within the body at the treatment area, which would lower the effectiveness of the regenerative medicine treatments. 

This bending of the science is harmful to our industry, which is why knowledgeable purveyors put one thing above all else– consistency. Our cellular concentrations are the same throughout each batch, and we make sure that there is a high ratio of viable cells. All of our samples are independently verified by a third party laboratory, and have been selected for their phenotypic and genotypic profile, characterized for optimum growth and stability. When the proper care is taken, Mesenchymal Stem Cell products have been identified as having the highest output of growth factors and stem cell factors among the current standards of care– as well as properties of angiogenesis, immunomodulation, and the potential for endogenous repair. 

Cellgenic has been working for over a decade, constantly reinventing itself and reinforcing the products that we offer with the latest advancements in the field of regenerative medicine. We take every painstaking measure possible to ensure that the cellular samples that our customers use to treat their patients are second to none– this includes the consistent concentrations of our sample, which are the same throughout ensuring that every patient gets the same treatment. We offer the product in 10 million or 30 million live total nucleated cells, where other fabricators would have the same number of total cells. We ensure that every single product that we send out has been tested for low amounts of annexin, which is a cellular protein which serves as a marker for cell death. 

All our Mesenchymal Stem Cell products come in 1cc vials cryogenically preserved– they are shipped overnight within the United States, conveniently delivered to your door in the morning. For use, the product is passively thawed between the palms of your hands– and ready to use when your patients are. MSC 10 contains 10 million live cells and is recommended for a single joint, or a small area. However, the MSC pure pro has 30 million live cells,and can be used for larger applications, or for up to three joints in the same patient at the same time. 

If you are interested in finding out more about Cellgenic MSCs, you can send an eMail to info@stemcellsgroup.com

Implications of Exosomes

As the newest field to regenerative medicine, it’s often exosomes therapy the least understood by those doctors newer to the field. While still not in use by many doctors, this is simply because it is new to the field. This is because many scientists are practically rabid to harnessthe benefits of this new treatment and apply them to target many of the conditions that modern medicine has allowed to slip through the cracks. 

Extracellular Vesicles and Exosomes 

The discovery of extracellular vesicles (EV), small bubbles composed of protein freely among cells, has been considered one of the greatest advancements in the field of medicine. They are broadly defined as something that exists outside of the cells of the human body, and they can be quite unique. Among these are exosomes, which has shown almost miraculous promise in treating inflammation, immunomodulation, cell-cell communication, and much more. Although it is certainly not a cure-all, it has been found to be good at what it does, which is almost a little bit of everything.This includes the communication and rejuvenation of all cells in the body, despite not actually being one itself. 

Exosomes are created by growing a healthy stem cell culture and disposing of the cells themselves– this leaves behind the exosomes, millions of them, that were created in the process. Due to their microscopic size, what is left behind must be ultra-centrifuged, as it is the only way to concentrate them enough to use them on a patient. Despite all of their abilities, the makeup of exosomes is really quite simple, amino acids and RNA– this means that, aside from bearing immunomodulatory properties, it can also be applied to a patient without causing an immune system reaction. This is a worry that modern physicians must constantly think about when implanting foreign objects into patients, that is one of the great benefits of the use of exosome therapy. 

An Overview on Exosome Therapy 

Generally defined, exosome therapy is the use of exosomes in a clinical setting, a new step forward that is being happily taken by physicians worldwide. Exosome Therapy has very rapidly become one of the most popular fields of regenerative medicine treatment around the world. Painstaking research has managed to highlight the practical uses of exosomes, and how they can be used to treat conditions including lyme disease, hair loss, and arthritis. This is because, while stem cells are largely responsible for the rejuvenation of older cells, they might not be able to supply the information required for healing to take place– and this is where exosomes come in. 

Consider exosomes the traffic conductors of regenerative medicine. They stimulate attention to damaged areas and work to control inflammation. In fact, many talented researchers believe that, by supporting the function of exosomes in the body, a better outcome could be obtained in patients. These scientific breakthroughs have fundamentally changed the healing process as we know it.  

Exosome therapy is minimally invasive, and most commonly used in patients that present with orthopedic injuries, but this is not it’s only use. It shows great applications for anti-aging medicine, and the treatment of inflammatory and degenerative diseases. Exosome treatments generally contain a combination of growth factors, messenger RNA, micro RNA, and cytokines. The resulting exosome treatment is used in conjunction with stem cell therapies to boost the healing process in patients. These exosome therapies can be administered directly into the affected area, but they can also be administered through IV drip for those that are looking to make use of the anti-aging properties of exosomes. 

Exosome injections are administered like other cellular therapies– administered directly into the part of the body affected by disease. In each case, patient dosing varies on condition and treatment plan, which means that there is no exact treatment protocol for exosome therapy. However, this allows physicians to fully customize them to a patient’s needs. 

What can Exosomes Treat?

As the field of regenerative medicine constantly grows, more and more treatments are discovered every month! However, researchers have been able to offer exosomes as an exciting alternative for a wide variety of illnesses, including in arthritis therapy– it is believed to play a large role in bone and cartilage remodeling.Exosome therapy currently shows promise in treating the following conditions: 

Hair Loss: Exosomes can be used to regrow hair due to their growth factor content. When injected exosomes trigger healing and the natural regeneration of hair follicles. 

Lyme Disease: Exosomes may be beneficial to patients who suffer from Lyme disease, which is a very complex disease that compromises the immune system. Because it results in an increase in inflammatory responses, incorporating exosomes into one’s treatment plan could help break the cycle of inflammatory response. 

Arthritis: Arthritis is known by many as the inflammation of the joints as a result of an autoimmune deficiency. Although various types of treatment are available to alleviate symptoms, nothing has been confirmed to reverse the disease’s progression.

Anti-Aging: Generally, aging can be thought of as a slow, steady inflammation of the body. Researchers have found a direct correlation between the number and types of exosomes within the body and the effects of aging, which means that exosome therapy could be used to reduce swelling in patients, and can be used to treat conditions such as crow’s feet, puffy eyes, and other markers of aging. 

Pain Management: On a similar vein, many pain symptoms are also the result of inflammation– this is why certain over-the-counter medications allow for the treating of light pain. But for severe, chronic conditions that cannot be treated with over the counter options, exosome therapy could be the key to increasing their quality of life. By targeting the pained area at the source of inflammation, exosome therapy can increase quality of movement and reduce pain in certain orthopedic conditions including stress injuries. 

As physicians around the world continue to study and apply exosomes, Global Stem Cells Group recognizes the fervent need to get these products into doctor’s hands. Our Cellgenic line has been in operation for years, helping physicians treat these conditions and more with exosome therapy.

GCell: The Newest All-In-One Solution in Regenerative Medicine

Are you a physician that is currently utilizing adipose tissue, but is growing tired of the time-consuming, arduous procedure? Are you having problems finding reagents that allow you to isolate stem cells? If so, GCell might be the solution for you. 

What is GCell? 

GCell is a revolutionary new machine that holds the potential to become the future of adipose stem cell processing. This is due to a variety of reasons, from the compactness of the unit, to its short processing time– it truly is a valuable implement in any regenerative medicine practitioner’s office. GCell employs a process of mechanical breakdown, which in addition to shortening the duration of the treatment, also serves to keep it within legal minimal-manipulation regulations. 

How Does GCell Work? 

Through a system of extremely small blades and filters, it is able to homogenize a sample of fat taken from anywhere in the body, making it into a slurry of growth factors, proteins, and the other components that make up the sample. The GCell then filters out the stromal vascular fraction cells, and uses a process called photoactivation to increase their vitality. Once the process is over, the end result is a final product that can be administered to patients within forty minutes from the sample’s harvesting. This is a far cry from the previous, muti-hour long treatments that physicians have grown accustomed to,  and this shortened timespan is something that both doctors and their patients will greatly appreciate.

regenerative medicine, traumatology

Why GCell? 

Additionally, it is a single-session treatment. This means that patients that wish to receive a GCell treatment will only have to visit their clinic once, and will not have to undergo any followup treatments. This machine provides the convenience of its small size and lightweight build with the ability to accelerate the stem cell harvesting process– but that isn’t all. The GCell has been designed to be an entirely enclosed system– this is important, as it means that samples that are run through the GCell will remain in a sterile environment, which preserves the viability of samples and ensures positive outcomes for patients. 

The GCell combines a grinder, a filter, and a photoactivation device, and is a turnkey solution that can take a physician from harvesting a fat sample to administering an injectable regenerative medicine therapy in less than an hour. GCell has been designed to be especially useful for clinics that are just beginning to implement regenerative medicine into their practice, but it’s all inclusive approach to stem cell isolation is what sets it a cut above the rest.  

regenerative medicine

GCell’s Single Session Treatment Protocol  

Unlike many other cellular therapies on the market, it is a single-session treatment, which means that there is no need for the patient to come back after his original treatment day has ended. This machine’s portability, small stature, and ability to accelerate the stem cell harvesting process makes it ideal for clinics that are just beginning to implement regenerative medicine into their practices, as it takes much of the rigor out of adipose-derived stem cell harvesting.

Self-Care for Dummies

It is, quite frankly, impossible to use the internet in the twenty-first century without hearing much more than you want to about Self-Care. Most often, it is some sort of internet influencer telling you how important it is to take care of yourself, while plugging their sponsored products. However, and many of these people may be remiss to see someone say this, self-care doesn’t require a lot of money in the bank. Indeed, just a few simple lifestyle changes can be all you need to give you a new lease on life. With the world as chaotic as it is right now, it is vital to our mental (and, by extension, physical) health to practice self-care. Below, we’ve given you a rundown on what self-care is, and how it is surprisingly important to your overall well being.

What is Self-Care? 

Put simply, self-care is being good to yourself and doing things that are good for you so that you feel better. Oftentimes, people do not have enough time in the day to consistently make the best choices possible. Other times, stress can get the better of them. It’s at these moments that it is important to take a step back, focus on our wellbeing, and make sure that we are taking care of ourselves. Self-care is not just about doing the things that you enjoy, it’s about doing the right thing. This means avoiding thighs that are unhealthy, including drugs, alcohol, or even toxic people– it’s caring for yourself like you would a friend in need.

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Self-Care and Mental Health

If you feel like you’re far too stressed out, like the entire weight of the world is on your shoulders and you are unsure of how to live with the burden, can’t focus, and are starting to feel depressed, then it is likely that you are suffering from something known as mental exhaustion. So, how do you get a clearer head? Many people find that exercising is very good for this, as it brings endorphins into the brain and gets the heart pumping. For those who already exercise, but have similar problems with stress and mental focus, another option is meditation. Take 30 minutes each day to sit in a quiet room, close your eyes, and just focus on your thoughts while taking deep breaths. Meditation has been in use for thousands of years as a way to relieve some of the mental burdens that weigh us down.

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Another thing that you can do is to take a break from social media or the internet. These days, people are bombarded with a constant barrage of information, whether it is advertisements, social media updates, news reports or app notifications. There’s way too much information out there, and our brains can’t handle it constantly. Reading a book before going to sleep is a great way to decompress– we all love TV, but books can stimulate our brain while allowing us to take it easy. If you are feeling overwhelmed, give your brain a noise from the constant noise and stimulus– mental health is important, and not something that should be taken for granted.

Self-Care and Physical Health

Taking care of your body is one of the cornerstones of self-care. If you are in good shape physically, and regularly exercise, it is very likely that your mind and spirit will be in as good a shape as your body. Living clean and caring for your physical health means cutting out fast food and junk foods, which are high in salt and sugar. These highly-processed products can mess with the brain, increase blood pressure, which can make you feel more anxious and stressed, and this is not even to mention the long-term effects hypertension can have on the health of your heart. When we are stressed, we gravitate towards the comfort foods that make us feel comfortable in the short term, those highly-processed, fatty foods  that can wreak havoc on our bodies in the long term. After all, there was no such thing as a bag of chips in the Paleolithic era, and in terms of the processes of evolution the human body has not progressed far from cavemen. Put simply, humans were never meant to eat potato chips and hamburgers– that doesn’t mean you can’t of course, but it means that you should eat these foods in moderation.

It is important to eat healthy foods such as vegetables, nuts, fruits, whole grains, and lean meats.  For the body, self-care also means exercise. You need to work out at least 45 minutes a day, 3-4 times a week. This will trigger the endorphins in your body, which help you to feel good and relax. Exercise is a great stress reliever, and it doesn’t need to be exclusively dumbbells, barbells, or other machines for heavy lifting. If you miss the gym days, however, I recommend combining IV drips with your routines to enhance both your performance and recovery.

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Going for a walk outside among nature can also help with your mental health. You can also practice yoga, which emphasizes a balance between the three parts that exist within humans– the mind, the spirit, and the body. There are many great fitness routines and activities that you can choose from to help give your body the care that it needs.

Self-Care for the Soul 

Emotional health is important as well. We often take for granted the emotions that we feel and, even more often, are unable to express them in ways that are healthy for us. Journaling is a good way to get in touch with what you are feeling. Expressing your thoughts and feelings on paper can give you some perspective on the situation, and help untangle what might feel like an impregnable wall of thoughts. Painting or drawing can also be a good release for your emotions, so is listening to music or, if you play an instrument, playing it yourself.

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Reaching out to friends and family just to talk can also release some of the feeling you may have bottled up after weeks or months of not properly expressing them. If things are bad, you can also find a good therapist to assist you in talking about your problems. They can give you some strategies to change your thinking and feel better– whatever you decide, make sure not to bottle up your feelings, because eventually they will spill out. And this hardly ever ends well.

Other Self-Care Tips 

Besides what we’ve mentioned above, we’ve created another blog post that contains more medically-oriented health tips for making sure that your body is operating properly. One important thing that you should do is to make sure that you are getting plenty of rest. A good night’s sleep is crucial, and most people require anywhere from 6-8 hours of sleep a night, but it varies from person to person, and some people might need more. Also, make sure that you are taking care of your hygiene as well. A long shower or bath could be just what you need to melt the stress of the day’s work away and leave you feeling refreshed and renewed. Make sure to avoid alcohol or drugs when dealing with stress, however– they will only make the problem worse. You can also drink herbal teas to help you relax and fortify your immune system, which has been found to be weaker when the body is stressed.

Really, you just need to remember to be good to yourself– treat yourself like a friend, and be kind. We are often our own worst enemies, and while this is mostly used in professional and social settings, it is also true when caring for yourself. After all, it is you who allows yourself to indulge in your worst impulses. Try to focus on your best impulses and taking care of yourself when you need it, and you’ll feel the difference.

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